GLP-2 TR specifications and molecular characteristics
The technical specification for GLP-2 TR, the GLP-2 TR research material supplied by GLP2 Labs: molecular formula C225H348N48O68, average molecular weight 4813.45 g/mol, 39 residues, supplied as a lyophilized powder. Each item is explained below.
Last updated
Specification table
| Product | GLP-2 TR |
|---|---|
| Type | Synthetic dual-receptor research peptide (39 residues) |
| Molecular formula | C225H348N48O68 |
| Molecular weight | 4813.45 g/mol (average) |
| Length | 39 residues |
| Sequence | Tyr-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-Aib-Leu-Asp-Lys-Ile-Ala-Gln-[Lys(C20 diacid-γGlu-2×AEEA)]-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 |
| Non-standard residues | Aib (2, 13) |
| Side-chain modification | Lys20: C20 diacid via γGlu-2×AEEA |
| C-terminus | Amide (Ser39-NH2) |
| Receptor design | GIP receptor (GIPR) and GLP-1 receptor (GLP-1R) |
| Form | Lyophilized powder |
| Vial sizes | 30 mg |
| Purity specification | ≥95% (HPLC-UV) |
| Purity, current lots | 99.77% |
| Identity specification | Confirmed by HPLC retention-time match |
| Testing laboratory | ILS Laboratories (independent) |
| Storage | Store sealed, dry and protected from light at the temperature stated on the vial label. Allow a cold vial to reach room temperature before opening. |
| Designation | Research use only |
Current lot results against specification
Every current lot meets the release specification. Current lots test at 99.77% by HPLC-UV against a specification of ≥95%, and identity is confirmed by HPLC retention-time match on every lot.
GLP-2 TR molecular formula
The molecular formula of GLP-2 TR is C225H348N48O68. Includes the 39 residues, the C-terminal amide and the lipid side chain on Lys20.
GLP-2 TR molecular weight
The average molecular weight of GLP-2 TR is 4813.45 g/mol. "Average" means it is calculated from natural isotope abundances.
GLP-2 TR sequence
Tyr-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-Aib-Leu-Asp-Lys-Ile-Ala-Gln-[Lys(C20 diacid-γGlu-2×AEEA)]-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
Structure and modifications
Aib at positions 2 and 13 adds a methyl group to the α-carbon and restricts backbone rotation. The lipid side chain on Lys20 (C20 diacid-γGlu-2×AEEA) makes the molecule strongly hydrophobic. The sequence contains one tryptophan (Trp25) and no methionine or cysteine.
Receptor classification
GLP-2 TR is designed for activity at the GIP receptor (GIPR) and GLP-1 receptor (GLP-1R). Both are class B G protein-coupled receptors.
Physical form
Lyophilized powder, recorded as the appearance on every certificate. Lyophilization (freeze-drying) removes water, which slows most chemical degradation. What lyophilized means.
Purity and identity specifications
GLP2 Labs’ stated release specification is ≥95% HPLC-UV purity with identity confirmed by HPLC retention-time match against a reference standard. The current lot, KB-52383, reported 99.77%. How purity is measured, or how specifications fit into the quality and supply-chain process.
Analytical and testing methods
HPLC-UV for purity, HPLC-RTM for identity and laboratory quantitation for net content, performed on every lot by ILS Laboratories. Each lot is also screened for fentanyl by immunoassay. LAL endotoxin testing (USP <85>) and PCR microbial screening are reported for lots where they were run. Testing and quality control.
Research designation
GLP-2 TR is designated research use only: supplied for laboratory research by qualified personnel. Research use only policy.
Buy GLP-2 TR
30 mg vials. Current lot KB-52383 tested at 99.77% purity with identity confirmed by HPLC retention-time match against a reference standard. Current purchasing is available through Klow.bio.