What GLP-2 TR is
GLP-2 TR is a synthetic 39-residue research peptide designed as an agonist at two class B G protein-coupled receptors: the GIP receptor (GIPR) and the GLP-1 receptor (GLP-1R). Its backbone contains two α-aminoisobutyric acid (Aib) residues, at positions 2 and 13, which constrain the chain and protect it from dipeptidyl peptidase-4, and lysine 20 carries a C20 fatty diacid attached through a γ-glutamate and two AEEA spacers. The C-terminal nine residues end in an amidated serine.
GLP2 Labs supplies GLP-2 TR as a lyophilized powder in 30 mg vials. Each lot is tested by ILS Laboratories for HPLC purity, identity against a reference standard and net content, with a fentanyl screen, and the result is published here before sale through Klow.bio.
"GLP-2 TR" is a product name for this two-receptor design. It is not glucagon-like peptide-2 (GLP-2), the natural 33-residue peptide cut from proglucagon, and it is not designed for the GLP-2 receptor. That is why GLP2 Labs identifies the material by its sequence, formula and lot results rather than by name alone.
Structure
Aib at positions 2 and 13 adds a methyl group to the α-carbon and restricts backbone rotation. The lipid side chain on Lys20 (C20 diacid-γGlu-2×AEEA) makes the molecule strongly hydrophobic. The sequence contains one tryptophan (Trp25) and no methionine or cysteine.
complete GLP-2 TR specifications.
Storage and handling
Store sealed, dry and protected from light at the temperature stated on the vial label. Allow a cold vial to reach room temperature before opening. Lyophilized material absorbs moisture from the air, and absorbed moisture restarts the reactions that drying slows, so keep vials sealed until needed. Storage and stability guide.